By Joyce Tombran-Tink, Colin J. Barnstable
Top educational and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize present medical and easy wisdom bearing on irregular progress of blood vessels within the eye, the reason for significant neovascular eye illnesses. The authors additionally determine and investigate the main promising techniques with strength for advertisement exploitation and talk about the demanding situations encountered in constructing therapeutics for ocular neovascular ailments. Highlights contain illuminating chapters on gene treatment and novel drug supply platforms and perfect summaries of the most recent healing ways. A spouse CD includes colour types of vital figures utilized in the e-book.
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Additional info for Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics (Ophthalmology Research)
A prospective study of cigarette smoking and risk of age-related macular degeneration in men. JAMA 1996;276:1147–1151. 13. Mitchell P, Wang JJ, Smith W, Leeder SR. Smoking and the 5-year incidence of age-related maculopathy: the Blue Mountains Eye Study. Arch Ophthalmol 2002;120:1357–1363. 14. Klein R, Klein BE, Tomany SC, Moss SE. Ten-year incidence of age-related maculopathy and smoking and drinking: the Beaver Dam Eye Study. Am J Epidemiol 2002;156:589–598. 15. Klein R, Klein BE, Tomany SC, Cruickshanks KJ.
123. Duh EJ, Yang HS, Haller JA, et al. Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor: implications for ocular angiogenesis. Am J Ophthalmol 2004;137:668–674. 124. Ogata N, Wada M, Otsuji T, Jo N, Tombran-Tink J, Matsumura M. Expression of pigment epithelium-derived factor in normal adult rat eye and experimental choroidal neovascularization. Invest Ophthalmol Vis Sci 2002;43:1168–1175. 125. Ohno-Matsui K, Morita I, Tombran-Tink J, et al. Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF.
Although PDT with verteporfin has been shown to be better than placebo for select cases, the need for multiple treatments, the high cost, and the rarity of visual improvement with this therapy (85) has led medical researchers to continue the search for a better treatment for CNV in AMD. Intravitreal and periocular injections of medicine have also been used to treat CNV. Intravitreal triamcinolone acetonide has been widely used in the management of CNV. A randomized, double-masked, placebo-controlled study by Gillies et al.
Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics (Ophthalmology Research) by Joyce Tombran-Tink, Colin J. Barnstable