Non-parametric optimal design in dose finding studies by O'Quigley J., Paoletti X. PDF

By O'Quigley J., Paoletti X.

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A method of writing proof scores of invariants for OTSs is described in (Ogata and Futatsugi, 2003c), which can be used for HOTSs. Modeling and Verification of Hybrid Systems Based on Equations Figure 1. 4. 47 Behavior of the temperature stabilizer. TEMPERATURE STABILIZER Let us consider a temperature stabilizer that keeps the temperature between and where The temperature stabilizer consists of two processors called Cooler and Heater. Cooler lowers the temperature per unit time if it is active, while Heater raises the temperature per unit time if it is active.

Section 4 presents a model checking approach towards formal verification of the AsmL specifications. In this section, the focus is put on the description of an on-the-fly algorithm and its functional parts consequently followed by the introduction of possible enhancement towards the efficient model checking of distributed systems. In Section 5 the related work is discussed. Finally, the paper concludes with a brief outlook on the future work in Section 6. 2. FRAMEWORK OVERVIEW The proposed verification framework is depicted by means of a process flow diagram shown in the Figure 1.

The only constraint imposed on a specification is related to the size of its state space that has to be finite. The model checking approach presented in the next sections obeys all these requirements. It can be classified as an on-the-fly approach working over the explicit ASM state. 1 On-the-fly model checking The intended model checking approach is depicted in the Figure 2. First of all, a particular AsmL specification and the property to be verified are provided as inputs. The property is specified in form of a temporal logic formula.

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Non-parametric optimal design in dose finding studies by O'Quigley J., Paoletti X.


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