Download e-book for iPad: Neurotoxins by P. Michael Conn (Eds.)

By P. Michael Conn (Eds.)

ISBN-10: 0121852652

ISBN-13: 9780121852658

ISBN-10: 0121852660

ISBN-13: 9780121852665

The beautiful simplicity and efficiency of poisons have made them priceless probes of neural structures. This e-book offers a accomplished compilation of thoughts used for the practise, dealing with, and, fairly, for using neurotoxins. version structures are defined within which those neurotoxins were super precious in constructing an realizing of the mobile and molecular foundation of secretion and electrophysiological occasions resulting in altered phone functionality.

Key Features
* handy benchtop format
* equipment awarded for simple edition to new systems
* A digital ''A-B-C'' of ordinary and on hand toxins
* complete protocols integrated for using alpha toxin, apamin, batrachotoxin; botulina toxin, bungarotoxin; channel ligands: agonists and antagonists; capsaicin; charybdotoxin, ciguatoxin; Clostridium botulinum neurotoxin; cholera toxin (choleragen); conotoxin; dendrotoxin; endothelin; fasciculin; geographutoxin; latrotoxin; typical pollution; neosurgatoxin; palytoxin; pertussis toxin; resiniferatoxin; sarafotoxin; scorpion toxin; snake venom toxins

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Additional info for Neurotoxins

Example text

Couraud, J. Biol. Chem. 259, 1491 (1984). a b c d e / h j flat-bottomed 1 [2] APAMIN 21 rated to d r y n e s s u n d e r a gentle stream of nitrogen at 4°C. 6), (2) 2 mCi N a I ( A m e r s h a m ) , and (3) an aliquot of 10 m M Tris-HCl buffer to bring the final reaction volume to 160 /zl. T h e Iodogen tube is incubated at r o o m t e m p e r a t u r e for 20 min, shaking intermittently, and then the c o n t e n t s d e c a n t e d into a clean plastic vial for 10 min. 0 and eluted with the same buffer (1ml fractions, ~ 8 ml/hr).

Neurosci. 10, 237 (1987). 15. G. B. Brown, S. C. Tieszen, J. W. Daly, J. E. Warnick, and E. X. Albuquerque, Cell. Mol. Neurobiol. 1, 19 (1981). 16. G. B. Brown, J. Neurosci. 6, 2064 (1986). 17. M. Cohen-Armon, H. Garty, and M. Sokolovsky, Biochemistry 27, 368 (1988). 18. M. Cohen-Armon and M. Sokolovsky, J. Biol. Chem. 261, 12498 (1986). 19. D. M. Soderlund, R. E. Grubs, and P. M. Adams, Comp. Biochem. Physiol. C 94C, 255 (1989). 20. E. T. McNeal and J. W. Daly, Neurochem. Int. 9, 487 (1986). 21.

T h e constituent h e a v y chain (HC) and light chain (LC) of B o N T s , of M ~ 100,000 and - 5 0 , 0 0 0 , respectively (Fig. 1), are held together by disulfide and noncovalent b o n d s . , B o N T type A ) ; the dichain form of the n e u r o t o x i n s has a higher toxicity than the single-chain form. Despite the lack of antigenic cross-reactivity a m o n g the serologically distinct B o N T s the c o m p a r i s o n of their amino acid composition indicates that they h a v e similar molecular sizes and share a c o m m o n subunit structure ( 1 - 4 ) .

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Neurotoxins by P. Michael Conn (Eds.)

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