By Daniel Ontaneda
The sector of a number of sclerosis (MS) therapy has replaced considerably over the last twenty years. Now 9 diverse brokers are licensed to be used in MS with a number of various routes of management, security features and efficacy profiles. For the clinician and sufferer the supply of brokers ability better flexibility and probabilities of disorder keep watch over. but the enlargement of suggestions has additionally made the therapy of MS an more and more advanced box. This e-book is meant to assist the overall neurologist, internist and pharmaceutical agent to speedy familiarize yourself with the present and destiny thoughts for treating relapsing sorts of MS.
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Additional info for Multiple sclerosis : a guide to pharmacologic treatment
Annu Rev Biochem 1998; 67: 227-64 Rep MH, Schrijver HM, van Lopik T, et al. Interferon (IFN)-beta treatment enhances CD95 and interleukin 10 expression but reduces interferon-gamma producing T cells in MS patients. J Neuroimmunol 1999; 96: 92-100 Sharief MK, Semra YK, Seidi OA, et al. Interferon-beta therapy downregulates the anti-apoptosis protein FLIP in T cells from patients with multiple sclerosis. J Neuroimmunol 2001; 120: 199-207 33 Multiple Sclerosis | A Guide to Pharmacologic Treatment 8.
No authors listed. Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: experience during the first three years. The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group. Neurology 1996; 47: 889-94 29. PRISMS Study Group and the University of British Columbia MS/MRI Analysis Group. PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS. Neurology 2001; 56: 1628-36 30. ; European Interferon Beta-1a IM Dose-Comparison Study Investigators.
Persistent neutralizing antibodies to natalizumab are associated with clearly worse clinical and imaging outcomes. Natalizumab is currently being studied in a large multi-center placebo controlled trial in secondary progressive MS. The study has not yet completed enrollment and results are not expected for at least another 3 years. 60 D. 4 SAFETY AND RISKS In phase III clinical trials natalizumab was associated with fatigue, allergic reaction and increased liver enzymes. An increase in nonserious infections has also been described and reactivations of herpes infections are notable.
Multiple sclerosis : a guide to pharmacologic treatment by Daniel Ontaneda