Download PDF by PD Dr. med. Stefan Milz, Professor Michael Benjamin,: Molecular Parameters Indicating Adaptation to Mechanical

By PD Dr. med. Stefan Milz, Professor Michael Benjamin, Professor Dr. med. Dr. hc. Reinhard Putz (auth.)

ISBN-10: 3540244743

ISBN-13: 9783540244745

ISBN-10: 354027832X

ISBN-13: 9783540278320

The current learn pursues the speculation that neighborhood compressive strength and the incidence of cartilage-specific transformation methods inside tendons and ligaments are without delay correlated.

In chosen anatomical samples of human starting place the distribution trend of yes elements of the extracellular matrix is classed. Investigations are conducted on the extensor tendons of feet and arms, on the transverse ligament of the atlas, on the transverse ligament of the acetabulum, and on the tendon of the very best indirect muscle and its trochlea. The molecular elements of the extracellular matrix are detected with standardized immunohistochemical methods.

The effects express that convinced molecules merely ensue as a result of compressive rigidity, others as a result of tensile pressure. The molecular spectrum of the extracellular matrix permits qualifying conclusions to the mechanical scenario of a given a part of the tissue.

The spatial growth of the fibrocartilaginous edition zones in tendons and ligaments approximately corresponds with the zones subjected to compressive strength; tensile rigidity by myself doesn't lead to a creation of fibrocartilage.

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Extra resources for Molecular Parameters Indicating Adaptation to Mechanical Stress in Fibrous Connective Tissue

Sample text

Usually, such a type of metachromasia occurs only if the tissue contains large quantities of strongly sulfated proteoglycans (Prento et al. 1991). The enthesis of the toe extensor tendons shows basically the same staining pattern as that of the finger extensor tendons (Lewis 1996). The only difference between the two entheses is that those areas of the toe entheses that are metachromatic and bear a positive labeling for type II collagen are considerably larger than the corresponding areas in the fingers.

Bar, 20 µm for both. (From Milz et al. ) The Transverse Ligament of the Acetabulum 37 38 Results of labeling for collagen VI detectable in the various parts of the ligament, a predominantly pericellular labeling can be observed primarily in the sesamoid and enthesis fibrocartilages. In the sesamoid fibrocartilage, the pronounced pericellular labeling is found in the immediate vicinity of the articular surface (Fig. 14). Pronounced labeling for type II collagen is characteristic of both the ventral and the dorsal enthesis fibrocartilages of all ligaments investigated (Fig.

The difference may not have anything to do with a wider tendon excursion, since there exist only minute differences between the fingers with regard to this parameter (Pahnke 1987). Particularly in the region of the MCP joints the differences are virtually nonexistent; rather, the tendon excursion is identical in the 2nd, 3rd, and 4th fingers (Elliot and McGrouther 1986). Likewise, it is improbable that differences between the fingers’ resting positions are significant, although the MCP joint of the index typically shows a less acute angle of flexion than the other fingers’ MCP joints (Jones 1941).

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Molecular Parameters Indicating Adaptation to Mechanical Stress in Fibrous Connective Tissue by PD Dr. med. Stefan Milz, Professor Michael Benjamin, Professor Dr. med. Dr. hc. Reinhard Putz (auth.)


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