By Thomas N. Sato (auth.), Cynthia A. Reinhart-King (eds.)
This quantity describes and discusses fresh advances in angiogenesis learn. The chapters are geared up to deal with all organic size scales of angiogenesis: molecular, mobile and tissue in either in vivo and in vitro settings. particular emphasis is given to novel methodologies and biomaterials which have been built and utilized to angiogenesis examine. Angiogenesis specialists from varied fields together with engineering, telephone and developmental biology, chemistry and physics might be invited to give a contribution chapters which specialize in the mechanical and chemical signs which have an effect on and advertise angiogenesis.
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Res. 100, 1164–1173 (2007) 52. : Targeting microRNA expression to regulate angiogenesis. Trends Pharmacol. Sci. 29, 12–15 (2008) 53. : Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells. Arterioscler. Thromb. Vasc. Biol. 28, 471–477 (2008) 54. : Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. PNAS 107(7), 3234–3239 (2009) 55. : MicroRNA-mediated integration of haemodynamics and Vegf signaling during angiogenesis.
J. Cell. Biochem. 96(6), 1110–1126 (2005) 22. : Molecular basis of the effects of shear stress on vascular endothelial cells. J. Biomech. 38(10), 1949–1971 (2005) 23. : Adhesion-dependent cell mechanosensitivity. Annu. Rev. Cell Dev. Biol. 19, 677–695 (2003) 24. : Role of proteoglycans in vascular mechanotransduction. Mechanosensitivity Cells Tissues 4(3), 219–236 (2011) 25. : Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress.
2 Microarray Analysis To identify the angiocrine signals that stimulate liver regeneration, we used microarray analysis (Fig. 9). Among the endothelial-specific genes, the transcription factor Id1 was specifically upregulated in the endothelial cells activated by PH . Using Id1venusYFP reporter mice in which the venus YFP expression is Mechanosensory Pathways in Angiocrine Mediated Tissue Regeneration 37 Fig. 9 Heatmap comparing transcriptional profiles. Tree view of the representative Affymetrix gene expression in the regenerative liver 48 h after partial hepatectomy (PH 48 h) compared to that of sham-operated mice (Sham 48 h).
Mechanical and Chemical Signaling in Angiogenesis by Thomas N. Sato (auth.), Cynthia A. Reinhart-King (eds.)