By Ehrhardt Proksch (auth.), Prof. Dr. Jens-Michael Schröder (eds.)
Fatty acids play a massive position within the barrier functionality of pores and skin and signify a massive resource of proinflammatory mediators similar to prostaglandins, leukotrienes and different lipids in inflammatory dermis problems. This ebook combines the 2 significant services of fatty acids in pores and skin biology. within the first half the biosynthesis of fatty acids in epidermis with its function in barrier functionality in addition to the function of nutritional fatty acids on dermis mobilephone functionality and within the therapy of inflammatory pores and skin illnesses is gifted. the second one half bargains with epidermis as a resource of proinflammatory eicosanoids, specially with the keratinocyte as a huge mobile resource. Metabolism of eicosanoids in epidermis, its position in psoriasis and atopic dermatitis in addition to pharmacological inhibition of eicosanoid biosynthesis is reviewed. The ebook finishes with a bankruptcy describing the tools used for quantification of fatty acids and derivatives in dermis irritation. someone attracted to dermis body structure would receive advantages from the overviews concerning the websites of fatty acids' functionality in dermis integrity and in pores and skin inflammation.
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Additional resources for Fatty Acids and Inflammatory Skin Diseases
Biochem Biophys Res Commun 133: 208213 Arachidonic acid metabolism in skin 138 Burall BA, Cheung M, Chiu A, Goetzl EJ (1988) Enzymatic properties of the 15-lipoxygenase of human cultured keratinocytes. ] Invest Dermatol71: 157-162 139 Green FA (1989) Generation of lipoxygenase products in normal and membrane-damaged cultured human keratinocytes. ] Invest Dermatol93: 486-491 140 Holtzman MJ, Turk J, Pentland A (1989) A regiospecific monooxygenase with novel stereopreference is the major pathway for arachidonic acid oxygenation in isolated epidermal cells.
In vivo activities of eicosanoids are summarized in Table 2. Eicosanoids in psoriasis Psoriasis is a chronic hyperinflammatory and hyperproliferative disease occurring in about 2 % of the Western population. The clinical appearance of the disease is characterized by sharply defined symmetrically located plaques of varying size from pinpoint to large plaques. The lesions are infiltrated, scaly and erythematous. Guttate psoriasis is characterized by small lesions, whereas the term 'chronic plaque psoriasis' is used for coin-sized to palm-sized plaques.
Arachidonic acid metabolites are indicated in bold face. (FLAP) was described . FLAP has been purified from rat neutrophil membranes  and cloned from rat basophil leukemia cell and human HL-60 cDNA libraries . It has been identified as an 18-kDa protein . So far all 5-LO-expressing cells investigated have been shown to contain FLAP. Also, transfection experiments have demonstrated that both FLAP and 5-LO must be present in order to transform AA into 5-HPETE . 5-HPETE is then further metabolized by 5-LO into LTA4 [70, 75] or transformed, either enzymatically by a glutathione-dependent peroxidase or nonenzymatically, into 5-HETE [76, 77].
Fatty Acids and Inflammatory Skin Diseases by Ehrhardt Proksch (auth.), Prof. Dr. Jens-Michael Schröder (eds.)