Download e-book for iPad: Diseases of the Liver & Biliary System, 11th edition by Shiela Sherlock, James Dooley

By Shiela Sherlock, James Dooley

ISBN-10: 0632055820

ISBN-13: 9780632055821

Illnesses of the Liver and Biliary approach is still one of many pre-eminent textbooks of selection for trainee in addition to training gastroenterologists. This new version will comprise up-to-date sections on viral hepatitis, within which every one kind of virus has its personal bankruptcy. on the grounds that this is often the quickest relocating region inside hepatology in the intervening time, the clearer demarcation of every virus might be a lot favored through the reader. there'll even be up to date sections on cholestasis, fulminant hepatitis and ascites. there'll be increased insurance of immunology of the liver and the position of cytokines in affliction and treatment. the easiest hepatology publication by way of integrating simple technology and medical knowledge each bankruptcy has been up-to-date with the latest advances within the examine and keep an eye on of hepatitis past ISBN 0865429065

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Additional resources for Diseases of the Liver & Biliary System, 11th edition

Sample text

Clin. Biochem. 1997; 34: 121. 8 Whitehead MW, Hawkes ND, Hainsworth I et al. A prospective study of the causes of notably raised aspartate aminotransferase of liver origin. Gut 1999; 45: 129. 2) [13] Chronic liver diseases pass through a long period of minimum non-specific symptoms (‘compensated’) until the final stage of ascites, jaundice, encephalopathy and pre-coma (‘decompensated’). Serum albumin and prothrombin time give some indication of the synthetic function of the liver, but this is usually maintained until late disease.

2. Quantitative hepatic function tests Site Substrate Function Other serum enzymes Cytosol Galactose* Microsome (cytochrome P450 system) Aminopyrine Caffeine Lignocaine Antipyrine Sinusoidal receptor membrane Galactoseterminated glycoprotein Galactokinase (phosphorylation) N-demethylation N-demethylation N-deethylation Hydroxylation/ demethylation Asialoglycoprotein receptor Lactic dehydrogenase (LDH) is a relatively insensitive index of hepato-cellular injury and is not routinely used. Marked increases are found in patients with neoplasms, especially with hepatic involvement.

Sakamoto M, Ueno T, Kin M et al. Ito cell contraction in response to endothelin-1 and substance P. Hepatology 1993; 18: 978. Selden C, Khalil M, Hodgson HJF et al. What keeps hepatocytes on the straight and narrow? Maintaining differentiated function in the liver. Gut 1999; 44: 443. Sell S. Heterogeneity and plasticity of hepatocyte lineage cells. Hepatology 2001; 33: 738. Skrainka B, Stahlhut J, Fullbeck CL et al. Measuring liver span. Bedside examination vs. ultrasound and scintiscan. J. Clin.

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Diseases of the Liver & Biliary System, 11th edition by Shiela Sherlock, James Dooley


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