By B. Skurkovich, S. Skurkovich (auth.), R. Numerof, C. A. Dinarello, K. Asadullah (eds.)
Cytokines and cytokine receptors stay a space of significant curiosity for the improvement of special cures for cutaneous inflammatory ailments. Anti-TNF therapeutics have confirmed to be potent within the therapy of psoriasis, and medical investigations have now began for different cytokine-directed remedies, similar to these concentrating on IFN-g, IL-12p40, and IL-18. as well as therapeutics that focus on cytokines without delay, ideas that concentrate on cytokine signaling pathways are in improvement. This publication summarizes the findings of the 56th foreign Workshop of the Ernst Schering learn beginning that fascinated about "Cytokines as capability healing pursuits for Inflammatory pores and skin Diseases".
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Additional info for Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases
2001). Coxsackie viruses may help bring about type I diabetes (Harrison and McColl 1998). Certain pediatric autoimmune neuropsychiatric diseases are associated with streptococcus (PANDAS), including obsessive-compulsive disorder and Tourette’s syndrome (Snider and Swedo 2003). A protein of Group A β-hemolytic streptococci has been implicated in psoriasis (Prinz 1997). Certain other skin diseases also appear to be associated with particular viruses, bacteria, fungi, possibly parasites, and sex hormones that may induce Th-1 cytokines.
Br J Dermatol 134 [Suppl 46]:12–5; discussion 38 Inhibition of IFN-γ in autoimmune diseases 21 Fierlbeck G, Rassner G, Muller C (1990) Psoriasis induced at the injection site of recombinant interferon gamma. Results of immunohistologic investigations. Arch Dermatol 126:351–355 Freyschmidt-Paul P, Z¨oller M, McElwee KJ, Sundberg J, Happle R, Hoffmann R (2004) The functional relevance of the type 1 cytokines IFN-γ and IL2 in alopecia areata of C3H/HeJ mice. Plenary Workshop on Alopecia Areata, The 4th Intercontinental Meeting of Hair Research Societies, Berlin, Germany, June 17–19 Gardella R, Belletti L, Zoppi N, Marini D, Barlati S, Colombi M (1996) Identiﬁcation of two splicing mutations in the collagen type VII gene (COL7A1)of a patient affected by the localisata variant of recessive dystrophic epidermolysis bullosa.
5 Conclusion TNF blockade has provided substantial advances in therapeutic options and pathogenetic insight in psoriasis. Novel cytokine entities offer further clinical utility to address remaining unmet clinical need, either as single agents or in potential immune modulatory combinations. IL-15 is expressed in psoriatic skin and when targeted in vivo provides substantial improvement in skin inﬂammation. Antibodies that target IL-15 are in phase II clinical trials in RA and are under consideration in other inﬂammatory conditions.
Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases by B. Skurkovich, S. Skurkovich (auth.), R. Numerof, C. A. Dinarello, K. Asadullah (eds.)