By Stewart Wolf, Allen K. Murray
The current quantity includes the edited transcript of a Totts hole Colloquium held might 19-21, 1980 backed through the Muscular Dystrophy organization. the purpose of the colloquium used to be to convey into concentration information in terms of telephone membranes that would give a contribution to realizing the pathogenic mechanism of Duchenne muscular dystrophy. an enormous obstacle to development in knowing the patho genesis of muscular dystrophy has been the failure, thus far, to spot the fundamental genetic disorder. Pending the id of the genetic lesion in Duchenne dystrophy and, in view of scattered yet power symptoms of a easy membrane disturbance, it appeared beneficial to discover in open discussion the present country of information of membrane morphology and chemistry with a watch to attainable leads for additional research. The members, drawn from a number of disciplines, tried to synthesize and reconcile their findings and to spot an important parts of lack of knowledge wanting exploration. For the main half they refrained from really good jargon and spoke in a language that may be understood via the remainder of the crowd. except delivering a assessment of generally various techniques to the research of the composition and behaviour of mobile membranes, the discussions introduced jointly present think~g on recommendations and techniques to the examine of the pathogenesis of muscular dystrophy. Already the private contacts made on the colloquium have resulted in new inter-institutional collabora tive investigations.
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Additional info for Composition and Function of Cell Membranes: Application to the Pathophysiology of Muscle Diseases
What's known about the of the Cytoskeleton effect of distortions in the cell if you stretch it or press on it mechanically? What do we know about the tension variation? If you break things can you see it all clearly with respect to the actin-spectrin interaction. DR. BRANTON: Well. it's known that in the absence of spectrin the membrane is much more fragile. in fact, characteristically, as you remove spectrin the membrane fragments although it need not do so if you treat it very gently. But usually if you are stirring even PHYLOGENY, STRUCTURE AND COMPOSITION OF CELL MEMBRANES 33 mildly as you are removing the spectrin by low ionic strength treatment as the spectrin elutes, the membrane vesicles frequently turn inside out and break into little pieces.
DR. SANDRA: I guess what I am saying is that I do not consider that proof of the inverted micelle. Is there convincing evidence for the flip-flop in inverted micelles? DR. de KRUIJFF: The proof of the inverted micelle stems from the fact that we do see a freeze fracturing inside the lipid bilayer structure. It is obvious it was formed from what you would expect from these lipid micelles. We see either a particle or a depression shown in the fracture plane either underneath or above the structure.
The human red cell has a defined shape that is attributable to a series of proteins which make up something called the red cell cytoskeleton. Cytoskeletons in general, in a variety of different eukaryotic cells are defined in terms of what there is after you have extracted the cell with a detergent. What is left after one extracts the variety of eukaryotic cells with a detergent such as Triton X-lOO is usually lIJade up of actin filaments containing the protein actin or intermediate filaments containing a protein such as ~1mentin and of micro tubules containing the protein tubulin.
Composition and Function of Cell Membranes: Application to the Pathophysiology of Muscle Diseases by Stewart Wolf, Allen K. Murray