Get Cellular Peptidases in Immune Functions and Diseases 2 PDF

By Uwe Lendeckel, Thilo Kähne, Dagmar Riemann, Klus Neubert, Marco Arndt, Dirk Reinhold (auth.), Jürgen Langner, Siegfried Ansorge (eds.)

ISBN-10: 0306463830

ISBN-13: 9780306463839

ISBN-10: 0306468263

ISBN-13: 9780306468261

Of the various distinctive roles performed by means of proteolytic enzymes in immune reactions, this booklet addresses diverse points of membrane peptidases, sign transduction through ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and rules of membrane peptidases in vivo and in vitro. a couple of newly came across peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are defined, with certain emphasis given to the position of peptidases in immune and protection reactions and within the pathogenesis of inflammatory and different illnesses, together with rheumatoid arthritis, pancreatitis, a number of sclerosis, Alzheimer's sickness and tumours of assorted origins. the focal point at the involvement of a variety of proteolytic enzymes in immune reactions and illnesses is a distinct characteristic of this multifaceted paintings , which mixes biochemical, immunological and scientific learn studies with literary stories of the sector.

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Immunol. 100: 277-283. , 1993, Demonstration of CD13/aminopeptidase N on synovial fluid T cells from patients with different forms ofjoint effusions. Immunobiol 187: 24-35. , 1994, Immunophenotype of lymphocytes in pericardial fluid frompatients with different forms of heart disease. Int. Arch. Allergy Immunol 104: 4856. Uwe Lendeckel, et al. , 1998, Role of members of the Wnt gene family in human hematopoiesis. Blood 92: 3189-3202. , 1990, The human aminopeptidase N gene: isolation, chromosome localization, and DNA polymorphism analysis.

Malfroy, B. C. (1982, Properties of "enkephalinase" from rat kidney: comparison of dipeptidyl-carboxypeptidase and endopeptidase activities. Biochem. Biophys. Res. Commun. 106: 276-285. McGwire, G. , 1997, Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B-virus binding protein. Life Sci. 60: 715-724. Uwe Lendeckel, et al. J. L. Beverly, S. J. ), University Press, Oxford, pp. 685-688. 11. Endocrinology 134: 2088-2094. , 1993, Biochemical and functional characterization of aminopeptidase N expressed by human melanoma cells.

Beside the previously reported induction of MAP kinase p42/Erk2 mRNA and activity, this is the second T cell signalling pathway found to be affected by inhibition of alanyl-aminopeptidase enzymatic activity. The mechanisms by 40 Modulation of WNT-5A expression by antinonin which actinonin enhances Wnt-5a expression remain to be established. Our data suggest that actinonin excerts its known anti-proliferative activity by preventing the early activation-dependent increase of Wnt-5a expression in T cells.

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Cellular Peptidases in Immune Functions and Diseases 2 by Uwe Lendeckel, Thilo Kähne, Dagmar Riemann, Klus Neubert, Marco Arndt, Dirk Reinhold (auth.), Jürgen Langner, Siegfried Ansorge (eds.)

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