Download e-book for kindle: Antiphospholipid Syndrome by A. Bulikova

By A. Bulikova

ISBN-10: 9535105264

ISBN-13: 9789535105268

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When closed native β2GPI was added to normal plasma or β2GPI-depleted plasma, no effect on an activated partial thromboplastin time (aPTT)-based clotting assay was observed. Structural Changes in β2-Glycoprotein I and the Antiphospholipid Syndrome 27 When open β2GPI was added to plasma or β2GPI-depleted plasma, the aPTT prolonged. , 2010). The presence of β2GPI in a certain conformation is dependent on the presence of anionic surfaces but also on the method of purification of β2GPI. As was described by Agar et al (2010), the conformation of β2GPI is dependent on the pH and salt concentration used during the purification of native β2GPI.

Thromb Haemost. In press. Arad A, Proulle V, Furie RA, Furie BC & Furie B. (2011) β₂-Glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model. Blood. 117(12), 3453-3459. Bevers EM & Galli M. (1990) Beta 2-glycoprotein I for binding of anticardiolipin antibodies to cardiolipin. Lancet. 336(8720), 952-953. Birdsall MA, Pattison NS & Chamley LW. (1992) Antiphospholipid antibodies in pregnancy. J Obstet Gynaecol.

1999) Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation. 99(15), 1997-2002. Polz E & Kostner GM. (1979) The binding of beta 2-glycoprotein-I to human serum lipoproteins: distribution among density fractions. FEBS Lett. 102(1), 183-186. Rioche M & Masseyeff R. (1974) Synthesis of plasma beta 2 glycoprotein I by human hepatoma cells in tissue culture. Biomedicine. 21(10), 420-423. Shi T, Iverson GM, Qi JC, Cockerill KA, Linnik MD, Konecny P & Krilis SA.

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Antiphospholipid Syndrome by A. Bulikova


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