By Lionel Fry
Thoroughly revised, this moment variation is a whole replace of the the world over acclaimed first version of An Atlas of Psoriasis, written through Lionel Fry, one of many world's so much distinct dermatologists. Copiously illustrated in colour, together with new top of the range visible imagery only in the near past on hand, the atlas is designed to exchange the previous version at the cabinets of dermatologists and dermatopathologists world wide. just like the earlier version, the ebook presents an authoritative assessment of psoriasis, together with medical good points, websites and medical styles, differential prognosis, psoriatic arthropathy, and remedy.
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Additional info for An Atlas of Psoriasis, Second Edition
Nod 2 has been shown to recognize peptidoglycan of Gram-positive organisms. Once the bacterial motifs are recognized by the cell-surface and intracellular receptors, the cells will produce cytokines, which in advanced mammals will attract lymphocytes and APCs into the tissue, and the so-called adaptive immune response will follow (Figure 14). Because psoriasis is triggered by the streptococcus and the fact that streptococcal peptidoglycan is found in increased quantity in psoriatic skin, it is possible that peptidoglycan may stimulate both the innate and, subsequently, the adaptive immune system in psoriasis (Figure 15).
The Koebner phenomenon does not occur in all patients. A patient may show variations in time between being Koebnerpositive and Koebner-negative. The nature of the injury is not specific. The clinical appearance of psoriasis in the Koebner phenomenon follows the site of injury. It may follow friction from tight clothing (Figure 55), follow a linear scratch (Figure 56), or occur at the site of an operation (Figure 57). ERYTHRODERMIC PSORIASIS Figure 54 Guttate psoriasis which has evolved into the plaque form This term is used when all the skin is involved in the psoriatic process (Figure 58).
Frequently, reddish-brown maculopapular lesions are also present (Figures 66–68) which are resolving pustules. The discoid lesions may be solitary or multiple. They may remain the same size or occasionally enlarge and may coalesce and affect large areas of the palms and soles. Sometimes there is no definite edge to the affected area, and it is mainly a collection of pustules with associated scaling and erythema. Localized pustular psoriasis may affect both palms and soles (in the same individual) or only the palms or soles.
An Atlas of Psoriasis, Second Edition by Lionel Fry